A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13
Identifieur interne : 001655 ( Main/Exploration ); précédent : 001654; suivant : 001656A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13
Auteurs : Margrith E. Knecht [Suisse] ; Michael Mayr [Suisse] ; Silvia Ferrari [Autriche] ; Friedrich Scheiflinger [Autriche] ; Marten Trendelenburg [Suisse]Source :
- Nephrology Dialysis Transplantation [ 0931-0509 ] ; 2010.
Abstract
In this case report, we describe for the first time a patient with thrombotic thrombocytopaenic purpura (TTP) accompanying highly active systemic lupus erythematosus (SLE) that was associated with non-neutralizing antibodies against the plasma metalloprotease ADAMTS13. Those non-neutralizing antibodies could have been the cause of ADAMTS13 depletion and consecutive TTP. More extensive analyses are required to determine the prevalence as well as the clinical relevance of non-neutralizing antibodies against ADAMTS13 in SLE patients.
Url:
DOI: 10.1093/ndt/gfq021
Affiliations:
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Those non-neutralizing antibodies could have been the cause of ADAMTS13 depletion and consecutive TTP. More extensive analyses are required to determine the prevalence as well as the clinical relevance of non-neutralizing antibodies against ADAMTS13 in SLE patients.</div></front></TEI><affiliations><list><country><li>Autriche</li><li>Suisse</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Suisse"><noRegion><name sortKey="Knecht, Margrith E" sort="Knecht, Margrith E" uniqKey="Knecht M" first="Margrith E." last="Knecht">Margrith E. Knecht</name></noRegion><name sortKey="Mayr, Michael" sort="Mayr, Michael" uniqKey="Mayr M" first="Michael" last="Mayr">Michael Mayr</name><name sortKey="Trendelenburg, Marten" sort="Trendelenburg, Marten" uniqKey="Trendelenburg M" first="Marten" last="Trendelenburg">Marten Trendelenburg</name><name sortKey="Trendelenburg, Marten" sort="Trendelenburg, Marten" uniqKey="Trendelenburg M" first="Marten" last="Trendelenburg">Marten Trendelenburg</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Ferrari, Silvia" sort="Ferrari, Silvia" uniqKey="Ferrari S" first="Silvia" last="Ferrari">Silvia Ferrari</name></region><name sortKey="Scheiflinger, Friedrich" sort="Scheiflinger, Friedrich" uniqKey="Scheiflinger F" first="Friedrich" last="Scheiflinger">Friedrich Scheiflinger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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